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KMID : 0191120100250020333
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Journal of Korean Medical Science
2010 Volume.25 No. 2 p.333 ~ p.335
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Use of Aripiprazole in Clozapine Induced Enuresis: Report of Two Cases
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Lee Myung-Ji
Kim Chul-Eung
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Abstract
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This report describes the efficacy of combined use of aripiprazole in the treatment of a patient with clozapine induced enuresis. Aripiprazole acts as a potential dopamine partial agonist and the dopamine blockade in the basal ganglia might be one of the causes of urinary incontinence and enuresis. We speculate that aripiprazole functioned as a D2 agonist in hypodopaminergic state of basal ganglia caused by clozapine and maintained dopamine level that would improve enuresis ultimately.
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KEYWORD
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Clozapine, Enuresis’Aripiprazole, Dopamine
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